Spider-Man: The Animated Series follows the adventures of Peter Parker, a college student in New York City, balancing the pressures of his personal life, schoolwork, and his secret life as the superhero Spider-Man. After being bitten by a radioactive spider, Peter gains spider-like abilities. While fighting crime and facing many of his classic villains, he must also manage relationships (such as with Mary Jane Watson and Felicia Hardy), maintain his academic performance, support his Aunt May, and deal with the antagonism of J. Jonah Jameson, publisher of the Daily Bugle, who blames Spider-Man for much of the city’s mischief. Wikipedia+2Apple TV+2

In Season 1, the show introduces many of Spider-Man’s iconic adversaries (e.g. Lizard, Doctor Octopus, Mysterio, Scorpion, Hobgoblin, Chameleon) and supporting characters. The episodes are mostly stand-alone stories rather than long arcs. spiderman-animated.fandom.com+2Wikipedia+2

One example: in the Season 1 premiere, “Night of the Lizard,” Peter Parker investigates large reptilian footprints in the subway and eventually discovers his college professor, Dr. Curt Connors, has transformed into the villainous Lizard after experimenting with a device called the “Neogenic Recombinator.” Marvel Database+1